Refine your search
Collections
Co-Authors
Journals
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Julkhuf, S.
- Anodic Polaroqraphic Determination of Isradipine in Pharmaceutical Formulations
Abstract Views :165 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, SA
1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, SA
Source
Scientia Pharmaceutica, Vol 72, No 2 (2004), Pagination: 131-142Abstract
The anodic behaviour of isradipine was studied using cyclic voltammetry (CV), direct current (DCt) and differential-pulse (DPP) polarography. Isradipine exhibited well-defined anodic polarographic waves over the pH range of 4-8 in Britton-Robinson buffer (BRb). At pH 6, the analytical pH, the diffusion-current constant (Id) was 2.12 ± 0.42 (n = 4). The oxidation potential is -0.1 0 V vs. Ag/AgCI reference electrode with correlation coefficients of 0.9977 and 0.9948 in the DCt and DPP modes, respectively. The current-concentration plots were rectilinear over the ranges 5-14 μg/ml and 2.4-12 μg/ml using the DCt and DPP modes, respectively. The lower detection limit was 1.12 μg/ml (3.02 × 10-6M) adopting the DPP mode. The proposed method was applied to commercial tablets and capsules, the % recoveries were 100.52 ± 1.267 and 99.4 ± 0.87 (n = 6) for the tablets and 101.3 ± 1.57 and 100.7 ± 2.10 (n = 6) for the capsules adopting both DCt and DPP modes, respectively. The number of electrons involved in the electrode process was accomplished and a proposal of the electrode reaction was presented.Keywords
Isradipine; Anodic Polarography; Dosage Forms.References
- Parfitt K. (Ed.). Martindale, The Complete Drug Reference 33rd Ed. The Pharmaceutical Press, Massachusetts 2002, 916-18.
- The British Pharmacopoeia. The Pharmaceutical Press, London 2000, 768-44.
- The United States Pharmacopoeia. The United States Pharmacopeial Convention, Rockville, MD 2001, 941-47.
- Mieclarek J. Normal-phase TLC separation of enantiomers of 1,4-dihydropyridine derivatives. Drug Dev. Ind. Pharm. 2001; 27: 175-79.
- Abd-Elghany M.F., Abd-Elkawy M., El-Zeany B., Stewart J.T. A stability-indicating high performance liquid chromatographic quantitation of isradipine in the presence of its degradation products. J. Planar Chromatogr. Mod. TLC 1996; 9: 290-92.
- Maurer H.M., Arit J.W. Screening procedure for detection of dihydropyridine calcium channel blockers metabolism in urine as part of a systemic toxicological analysis procedure for acidic compounds by gas-chromatography (GC-MS) after extractive methylation. J. Anal. Toxicol. 1999; 23: 73-80.
- Jean C., Laplanche R. Assay of isradipine and of its major metabolites in biological fluids by capillary gas chromatography and chemical-ionisation mass spectrometry. J. Chromatogr. B. 1988; 72: 61-69.
- Christensen H.R., Angelo H.R., Skajaa K. Determination of isradipine and its metabolite in serum by capillary column gas chromatography with nitrogen selective detection. J. Chromatogr. B. 1992; 112: 161-65.
- Rask H.S., Angelo H.R., Christensen H.R. Enantioselective determination of isradipine in human serum using chiral stationary phase liquid chromatography and gas chromatography with nitrogen selective detection. Chirality, 1998; 10: 808-812.
- Tesarova E., Gilar M., Hobza P., Kabelac M., Deyl Z., Smolkova-Keulemanosova E. Correlation between structure of dihydropyridine calcium antagonists and their retention behaviour and enantioseparation on the β-cyclodextrin stationary phase in HPLC. J. High Reslut. Chromatogr. 1995; 18: 597-601.
- Okamoto Y., Aburatani R., Hata K., Honda M., lnotsume N., Nakano M. Optical resolution of dihyropyridine enantiomers by high performance liquid chromatography using phenylcarbamates as a chiral stationary phase. J. Chromatogr. 1990; 513: 375-78.
- Takamura K., Kusus F., Abdel-Wadood H., El-Rabbat N., Saleh G., Refaat I. Redox properties of isradipine and its electrochemical detection in the HPLC determination of the compound in human serum. Biomed. Chromatogr. 2000; 14: 453-58.
- Bartlett M.G., Spell J.C, Mathis P.S., Abdel-Ghany M.F., El-Zeany B.E., Abdel-Kawy M., Stewart J.T. Determination of degradation products from calcium-channel blocker isradipine. J. Pharm. Biomed. Anal. 1998; 18: 335-45.
- Abdel-Ghany M.F., El-Zeany B.E., Abdel-Kawy M., Stewart J.T. A stability-indicatng high performance liquid chromatographic assay of isradipine in pharmaceutical preparations. Anal. Lett. 1996; 29: 1157-1165.
- Kuesters E., Dosenbach C., Geber G. Enantiomeric separation of isradipine and related compounds by liquid chromatography with a chiral stationary phase. J. High Resolut. Chromatogr. 1991; 14: 769-771.
- Boutagy J., Ramble F., Dunagan F. Determination of isradipine and the oxidative pyridine metabolite in human plasma by high performance liquid chromatography. J. Chromatogr. 1989; 79: 483-88.
- Al-Suwyeh S.A., Quick, simple and sensitive HPLC method for the determination of isradipine in plasma and its application in pharmacokinetic studies. Anal. Lett. 2002; 35: 1205-1213.
- Belal F., Al-Majed A., Julkhuf S. Voltammetric determination of isradipine in dosage forms and spiked human urine and plasma. J. Pharm. Biomed. Anal. 2003; 31 : 989-98.
- Albini A. and Fasani E., editor, Drugs Photochemistry and Photostability. The Royal Society of Chemistry, Cambridge 1998, 21-23.
- Heyrovsky J., Zuman P. Practical Polarography. Academic Press, New York, 1965, 163.
- Meites L., Israel Y. The calculation of electrochemical kinetic parameters from polarographic current-potential curves. J. Am. Chem. Soc. 1961; 83: 4903-4907.
- Proszt J., Cieleszky V., Gyijrbiro K. Polarographie. Akademiai Kiado, Budapest 1967,385-91.
- HeyrovskyJ., Kuta J. Principles of Polarography. Academic Press, New York, 1968, 163-65.
- Squella J.A., Barnafi E., Perna S., Nunez-Vergara L.J. Nifepidine: differential pulse polarography and photodecomposition. Talanta, 1989; 36: 363-367.
- Miller J.C., Miller J.N. Statistics for Analytical Chemistry. John Wiley and Sons, New York 1983,83-87.